Fig. 3
Conserved domains in LRP sequences. Blue boxes represent low-density lipoprotein receptor repeat class B domains. Gold boxes represent calcium-binding EGF-like domains. Green boxes represent low-density lipoprotein receptor class A domains. a Pattern of conserved domains in Arrow/LRP5/6 orthologs. b General pattern of conserved domains in Arrow/LRP5/6 orthologs. c Pattern of conserved domains in the best matches to Arrow/LRP5/6 in species that have lost several Wnt ligands. The lower case letter after the H. miamia sequence does not indicate specific orthology. The specific orthology of this sequence is unclear based on our analyses. The S. mediterranea sequence represents a highly derived Arrow/LRP5/6 ortholog based on functional analyses [98]