From: Diversity and evolution of ABC proteins in mycorrhiza-forming fungi
Group | Function | References | ||
---|---|---|---|---|
ABC-A | Biological function in fungi unknown, but Magnaporthe grisea transporter Abc4 is required for appresoria formation. Mammalian ABC-A transporters are involved in lipid transport and metabolism | |||
ABC-B | full | ABCB1 | Export of mating pheromones | |
ABCB2 | Multidrug resistance; a specific group of ABCB transporters in ascomycetes (but not in Agaricomycotina) is associated with the biosynthesis cluster for the hydroxamate-type siderophores and might have a role in their metabolism. | |||
half | ABCB3 | Export of the mitochondria-synthesized precursors of iron-sulfur (Fe/S) clusters; localised to the inner membrane of mitochondria | ||
ABCB4 | Heavy-metal resistance; localized to the vacuolar membrane | |||
ABCB5 | Transporter of the inner mitochondrial membrane involved in the export of peptides released upon proteolysis by m-AAA protease | |||
ABCB6 | Unknown | Â | ||
ABC-C | ABCC1 | Vacuolar import of phosphatidylcholine; bile acid transport | ||
ABCC2 | Unknown | Â | ||
ABCC3 | Unknown | Â | ||
ABCC4 | Unknown | Â | ||
ABCC5 | Unknown; often associated with the secondary metabolism gene clusters | |||
ABCC6 | Heavy metal resistance; vacuolar uptake of glutathione conjugates; localized to vacuolar membrane | |||
ABCC7 | Drug resistance; heavy metal resistance | |||
ABC-D | ABCD1 | Import of long-chain fatty acids into peroxisomes | [53] | |
ABCD2 | Import of long-chain fatty acids into peroxisomes | [53] | ||
ABCD3/4 | Unknown | Â | ||
ABC-E | Ribosome biogenesis and assembly of translational pre-initiation complexes | |||
ABC-F | ABCF1 | Biogenesis of 40S and 60S ribosomal subunits | [56] | |
ABCF2 | Regulation of mRNA translation; positive regulator of Gcn2p kinase activity | [57] | ||
ABCF3 | Unknown | Â | ||
ABCF4 | mRNA export factor | [58] | ||
ABCF5 | Translation elongation factor | |||
ABC-G | ABCG1-5 | Pleiotropic drug resistance; weak organic acid tolerace; export of toxic metabolites, sterol uptake, translocation of membrane phospholipids and quorum sensing | ||
ABCG6 | Unknown | Â | ||
ABCG7 | Unknown; are characterised by a presence of EGF domain | |||
ABC-I | ABCI1 | Part of the CCR4-NOT transcriptional regulatory complex | [62] | |
ABCI2 | Unknown | Â | ||
ABCI3 | Unknown | Â |