Figure 5From: Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymesA negative association of betweenness centrality and selective constraint. The log10 transformed betweenness centrality for each reaction (x-axis) is plotted against the estimated selective constraint (ω) for its associated genes. The correlation between these two variables is negative and weak (Pearson's r = -0.222, Spearman's r = -0.279), but highly significant (P < 10-4).Back to article page