Figure 7

Genomic neighborhood surrounding the lactalbumin ( Lalba ) and calcium-binding lysozyme ( Lysc1 ) genes. The relative organization and orientation (arrowheads indicated direction of transcription) of genes near the Lalba and Lysc1 genes in representative genomes from Ensembl [16]. Species and chromosome (or SuperContig for platypus) are indicated below each gene array. Gene sizes and distances are not to scale. The distance between the human LALBA and CCNT1 genes is about 150 kb. Gene symbols are: OLFR, a member of the Olfactory receptor gene family; C12orf41, chromosome 12 open reading frame 41; CCNT1, Cyclin-T1 (CycT1, Cyclin-T); Mip, major intrinsic protein of lens fiber; Spryd4, SPRY domain containing 4; Gls2, glutaminase 2. A large sequence gap exists in the cow genome, indicated by the parentheses, near the expected location of the Lysc1 gene. The platypus Lalba gene is on a small contig, as indicated by the shorter line flanked by dotted lines, that has not been annotated to contain (nor do we find) any other genes. Genes in the horse genome (not shown) are organized similar to those shown for the dog. Genes in the chimpanzee, gorilla, orangutan, baboon, and elephant genomes (not shown) are similar to those of the human and macaque. Genes in the rat and guinea pig genomes (not shown) are similar to those of the mouse.