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Fig. 5 | BMC Ecology and Evolution

Fig. 5

From: Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones

Fig. 5

Breast and lung cancer cell lines can increase each other’s migration potential. a The effect of CM collected from MDA or H2122 AS on the migration of MCF7. b The effect of the TGF-β receptor I inhibitor (TGFβRI) on the MCF7 migration induced by H2122AS_CM (wound-healing assay; 48 h). c The effect of MDA_CM on the migration of H2122 AS; d The effect of the TGF-β receptor I inhibitor on the H2122 AS migration induced by MDA_CM (wound-healing assay; 48 h). Y axis: Percentage of the occupied area. CT–Control/Constitutive migration. Error bars indicate SEM (n = 3). + refers to control (CT), and * refers to treatments. ns = not significant; + /* and +++/*** denote p < 0.05 and p < 0.001, respectively

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BMC Ecology and Evolution

ISSN: 2730-7182

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