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Fig. 1 | BMC Ecology and Evolution

Fig. 1

From: Molecular evolution of hatching enzymes and their paralogous genes in vertebrates

Fig. 1

Molecular evolution of C6ast genes (HE, pastn, npsn, pac, and C6ast4/5) that have been considered to date. The molecular evolution of the C6ast genes is schematically shown. The C6ast genes have been identified to have two extra Cys (red diamonds in dotted box) in the protease domain compared to other astacin-family proteases having four conserved Cys residues (black diamonds in dotted box). The HE of non-teleostean fishes have CUB domain structures at the C-terminal side of astacin domain, like BMP1, while the HE and C6ast of teleosts have no domain structure at the C-terminal side of astacin domain. From the characteristics of these conserved Cys residues and domain structure, it has been previously thought that the C6ast gene arose by gene duplication of the HE gene in the common ancestor of teleosts

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