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Table 1 TLR genome/transcriptome survey results and classification of TLRs included in the phylogenetic analysis

From: The evolution of the metazoan Toll receptor family and its expression during protostome development

Species

TLRs

V-type/scc

P-type/mcc

NC

References

Cnidaria

 Nematostella vectensis

1

0

1

0

L: [27]

 Acropora digitifera

4

1

3

0

L: [72]

 Acropora millepora

1

0

1

0

L: [72]

 Orbicella faveolata

1

0

1

0

L: [83]

Xenacoelomorpha

 Xenoturbella profunda

0

0

0

0

G: Unpublished

 Hofstenia miamia

0

0

0

0

G: GCA004352715

 Praesagittifera naikaiensis

0

0

0

0

G: PRJDB7329

 Isodiametra pulchra

0

0

0

0

G: Unpublished

 Meara stichopi

0

0

0

0

G: Unpublished

 Convolutriloba macropyga

0

0

0

0

T: [100]

Spiralia

 Bryozoa

  Membranipora membranacea

6

4

1

1

T: SRX1121923

  Bugula neritina

0

0

0

0

T: [101]

 Cycliophora

  Symbion pandora

0

0

0

0

T: [102]

 Annelida

  Galathowenia oculata

39

18

12

9

T: Unpublished

  Eisenia fetida

11

0

1

10

T: SRX3108745

  Helobdella robusta

4

1

3

0

G: [103]

  Phyllochaetopterus prolifica

3

1

0

2

L: [66]

 Mollusca

  Crassostrea gigas

12

10

2

0

G: [104]

  Octopus bimaculoides

9

1

6

2

G: [105]

  Cyclina sinensis

2

1

1

0

L: [88]

  Leptochiton rugatus

1

0

0

1

L: [66]

  Biomphalaria glabrata

27

16

10

1

G: [87]/NCBI

 Brachiopoda

  Terebratalia transversa

15

4

4

7

T: [100]

  Hemithris psittacea

6

3

1

2

T: [66]

  Lingula anatina

25

15

7

3

G: [106]

 Micrognathozoa

  Limnogathia maerski

0

0

0

0

T: SRX1121929

 Gastrotricha

  Lepidodermella squamata

0

0

0

0

T: [107]

  Macrodasys sp

0

0

0

0

T: [108]

  Megadasys sp

0

0

0

0

T: [108]

  Diuronotus aspetos

0

0

0

0

T: SRX1121926

  Mesodasys laticaudatus

0

0

0

0

T: SRX872416

 Nemertea

  Lineus longissimus

10

7

2

1

T: [100]

  Lineus ruber

6

2

3

1

T: Unpublished

  Notospermus geniculatus

7

5

1

1

G: [89]

  Paranemertes peregrina

2

1

0

1

L: [66]

 Phoronida

  Phoronopsis harmeri

2

0

1

1

T: SRX1121914

  Phoronis australis

24

14

8

2

G: [89]

  Phoronis psammophila

3

1

1

1

L: [66]

  Phoronis vancouverensis

6

5

0

1

L: [66]

 Platyhelminthes

  Macrostomum lignano

0

0

0

0

G: [109]

  Echinococcus multilocularis

0

0

0

0

G: [110]

  Hymenolepis microstoma

0

0

0

0

G: [110]

 Rotifera

  Epiphanes senta

1

1

0

0

T: Unpublished

  Rotaria tardigrada

0

0

0

0

T: [111]

  Echinorhynchus gadi

0

0

0

0

T: SRX1121912

  Macracanthorhynchus hirudinaceus

0

0

0

0

T: [108]

Ecdysozoa

 Priapulida

  Priapulus caudatus

3

0

3

0

T: [100]

  Halicryptus spinulosus

4

1

3

0

T: [100]

 Tardigrada

  Hypsibius exemplaris

1

0

1

0

G: [112]

  Ramazzottius varieornatus

1

0

1

0

G: [113]

 Onychophora

  Peripatopsis capensis

1

0

0

1

T: [114]

 Nematoda

  Loa loa

1

0

1

0

G: [115]

  Onchocerca volvulus

1

0

1

0

G: [116]

  Caenorhabditis elegans

1

0

1

0

L: NCBI

 Loricifera

  Armorloricus elegans

2

1

1

0

T: SRX1120677

 Arthropoda

  Daphnia pulex

5

2

3

0

G: [117]

  Drosophila melanogaster

9

1

8

0

L: NCBI

  Ixodes scapularis

5

1

3

1

L: [118]

Deuterostomia

 Tunicata

  Ciona intestinalis

2

1

1

0

L: [97]

  Oikopleura dioica

1

1

0

0

L: [96]

 Echinodermata

  Strongylocentrotus purpuratus

8

7

1

0

L: [64]

 Craniata

  Homo sapiens

10

10

0

0

L: NCBI

  1. NC column indicates the number of TLRs that could not be classified for each species. In the reference column it is indicated whether the survey was performed in a genome (G) or a transcriptome (T), followed by the reference or NCBI accession number in case the genome/transcriptome was published. TLR sequences extracted directly from the literature and, therefore, were not obtained in our genomic and transcriptomic surveys, are indicated with an L. NCBI indicates that sequences were collected individually from NCBI database. For further details, see Additional file 4: Table S2