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Fig. 1 | BMC Ecology and Evolution

Fig. 1

From: Divergent patterns of selection on metabolite levels and gene expression

Fig. 1

Metabolic Profiling of F2 haploid segregants from a cross between BY and RM. A Eight metabolites produced in the late ergosterol biosynthesis pathway were profiled using targeted metabolomics with UHPLC-MS in 74 haploid F2 segregants from a cross between the BY (laboratory) and RM (wine) strains (genes previously shown to be under selection in [11] for gene expression in red). Structures shown for metabolites measured. B Between technical replicate pearson correlation of ergosterol level for 73 F2 segregants with technical replicates, metabolite levels scaled by the mean normalized peak area for the segregants. C Correlations between the different measured metabolite levels for the segregants (mean of technical replicates). D Diagram depicting the traffic jam model in which a reduction in enzyme levels along a section of a linear pathway leads to build up of precursor metabolites and reduction in pathway end products, as well as an unobstructed metabolic pathway. E Metabolite levels for the three biological replicates of BY and RM scaled to the mean of the three RM biological replicates

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