Positive natural selection in primate genes of the type I interferon response

Table 1 Some examples of genes in Type I interferon pathways that bear the signature of successive rounds of positive natural selection

Category	Gene under positive selection	Known direct virus interactions	Literature showing positive selection
induction	MB21D1/cGAS	Many classes of viruses	Mozzi et al. 2015, Ma et al. 2016
Induction	IFI16	HCMV	van der Lee 2017, Dell’Oste et al. 2014
Induction	ISG15	Influenza	Zhao et al. 2013, Zhao et al. 2010
Induction	MAVS	Hepatitis C virus	van der Lee 2017, Anggakusuma et al. 2016
Induction	STING	Flaviviruses	Mozzi et al. 2015, Stabell et al. 2018, Ding et al. 2018
Induction	TRIM25	Influenza	Malfavon-Borja et al. 2013, Gack et al. 2009
ISG	ADAR	RNA viruses	Forni et al. 2014, Pfaller et al. 2018
ISG	MxB	Many classes of viruses	Mitchell et al. 2015, Haller et al. 2011
ISG	EIF2AK2/PKR	Influenza	Elde et al. 2009, Dauber et al. 2009
ISG	RNAse L	TMEV	van der Lee 2017, Sorgeloos et al. 2013
ISG	Tetherin	HIV	Lim et al. 2010, McNatt et al. 2009
ISG	TRIM15	Retroviruses	Malfavon-Borja et al. 2013, Uchil et al. 2008
ISG	TRIM22	Influenza	Sawyer et al. 2007, Di Pietro et al. 2013
ISG	TRIM31	Retroviruses	Malfavon-Borja et al. 2013, Uchil et al. 2008
ISG	TRIM38	Retroviruses	Malfavon-Borja et al. 2013, Uchil et al. 2008
ISG	TRIM5α	HIV	Johnson et al. 2009, Sawyer et al. 2005
ISG	RSAD2/Viperin	RNA viruses	Lim et al. 2012, Panayiotou et al. 2018
ISG	SAMHD1	HIV-2	Laguette et al. 2012, Coquel et al. 2018

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