The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

Table 1 Average conservation score for the different protein domains

Protein	Protein domain	Positions	Conservation score (mean ± SEM)
HAP40	N-terminal domain	1 − 216	− 0.14 ± 0.07
	Central proline-rich region	217 − 258	0.80 ± 0.12
	C-terminal domain	259 − 371	− 0.03 ± 0.09
HTT	N-HEAT	91 − 1684	− 0.09 ± 0.02
	Insertion	400 − 674	0.48 ± 0.06
	N-HEAT without insertion	91 − 399 + 675 − 1684	− 0.20 ± 0.03
	C-HEAT	2092 − 3098	0.35 ± 0.05
	C-HEAT without insertions	2092 − 2120 + 2457 − 2509 + 2664 − 3098	− 0.45 ± 0.03
	Insertion 1	2121 − 2456	0.59 ± 0.06
	Insertion 2	2510 − 2663	− 0.07 ± 0.07
	Bridge	1685 − 2091	− 0.05 ± 0.05

Conservation scores calculated with the ConSurf method [26] as outlined in the method section. Information about the location of HTT domains was taken from Guo et al. [11]. Calculations of the mean and standard error of mean (SEM) were performed using R version 3.5.2 [64] and the R-package readr [66]

ISSN: 2730-7182