Mutations | Major changes in residue number | Major shifts in region | Critical region |
---|---|---|---|
Ile93Met | 23–24 | C12-peptidase Domain | 32–39 (Secretion, Signal Motif) |
32–38 | Secretion signal Motif | ||
45,74–75 | |||
136,148 | |||
222–223 | Farnesylation site | ||
Glu7Ala | 22–25 | C12- peptidase Domain | 32–39(Secretion, Signal Motif) |
31–38 | Secretion signal Motif | ||
45,74–75 | |||
111–112 | |||
190–191,136 | CK2 Phosphorylation site | ||
Ser18Tyr | 23–25, | C12 peptidase Domain | 32–39 (Secretion, Signal Motif) |
31–38, | Secretion signal Motif | ||
45,74–75 | |||
111–112 | |||
150–152 | |||
148,136 | |||
222–223 | Farnesylation site | ||
Arg178Gln | 23–24 | C12-peptidase Domain | 32–39(Secretion, Signal Motif |
32–39 | Secretion signal Motif | ||
136,74 | |||
221–223 | Farnesylation site | ||
Ala216Asp | 23–24 | C12-peptidase Domain | |
74–75 | ___ | ||
136,148 | |||
222–223 | Farnesylation site |