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Table 2 Structural comparisons of predicted ancestral UCHL1 proteins

From: Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Comparison between lineages

Major change in backbone torsion angles

Major shifts in region

Critical region

Mammals Primates ancestor

Leu32-Gly40

Pro43-Ala46, Lys71-Ser76, Gln103-Gly111, Asn136,

Glu149-Arg153,

Gly210-Valn212

Secretion Signal motif

C12- Peptidase domain

C-terminal region

32–39 (Secretion Signal Motif)

Primates Simians ancestor

Ser41-Val43, Ala48-Leu50, Gln84-Gly87, Glu109-Gly111,

Gly150-Asp156,

Gly210-Ser215,

Ala222-Ala223

C12-peptidase Domain

C-Terminal region

Farnesylation site

___

Simians Apes/human ancestor

Val31-Gly39

Ser41-Val42, Glu208-Ser215, Glu149-Cys152,

Val154-Asn159,

Glu203

Secretion Signal motif

C12- Peptidase domain

C Terminal region

32–39 (Secretion Signal Motif)

  1. This table shows the effect of lineage specific substitutions on the backbone torsion angles of ancestral UCHL1 protein structures through comparisons among lineages given in first column