Skip to main content
Fig. 4 | BMC Evolutionary Biology

Fig. 4

From: Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6

Fig. 4

Integrated haplotype score (iHS) and extended haplotype homozygosity (EHH) plots for selected populations. ad Manhattan plots of standardized |iHS| statistics for selected populations. The dashed horizontal lines represent the cut-off for extreme |iHS| scores (|iHS | > 2), representing the most extreme 5% of empirical |iHS| values. The red dots in plots represent outlier SNPs in and/or near LTα; (E–H) EHH plots for selected populations show the decay of identity of haplotypes on chromosomes with a derived allele (the blue line) versus an ancestral allele (the red line) at core SNPs as a function of distance. The distance from the core SNP (at zero) is displayed on the x-axis; the negative numbers indicate distance upstream from the core SNP, while positive values indicate distance downstream from the core SNP. The EHH values are shown on the y-axis. It is important to note that these EHH plots are selected examples from a larger set of EHH curves that were generated in the present study, which can be found in Additional file 1: Figure S5)

Back to article page