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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks

Fig. 2

In silico structure model of the CgADAR1 deamination domain. a. Superimposition of the modeled structure of CgADAR1 (green cartoon) to the template HsADAR2 (pale orange cartoon) in complex with dsRNA (PDB ID: 5HP3). The active sites with the RNA flipped base are framed into the black box. b. Magnification of the superimposed active sites. Important residues for the protein’s activity and dsRNA binding, and mutated ones in ADAR1s respect to ADAR2s are represented in sticks. Surface representation of HsADAR2 (c) and CgADAR1 (d) active sites in the dsRNA bound state (represented in dark gray sticks). White arrows indicate the RNA phosphate groups (3′ left, 5′ right) of the flipped, deaminated base, anchored to conserved HsADAR2 residues which are mutated in CgADAR1. Worthy of note is the different steric hindrance and charge distribution of the active sites due to these mutations

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