Fig. 5From: On estimating evolutionary probabilities of population variantsEvolutionary probability (EP) values for human missense variants using the standard and modified methods. The EP values on the x-axis are binned by 0.05 EP increments, with black points representing the mean EP of the (a) modified EP approach in which both species relationships and divergence times were estimated separately for each sequence alignment (ML-RelTime), and (b) modified EP approach in which only the divergence time was estimated and species relationships (Fig. 9) were assumed (RelTime Only). The gray areas represent the one standard deviation around the mean EP for the modified methodsBack to article page