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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Recently evolved human-specific methylated regions are enriched in schizophrenia signals

Fig. 1

Enrichment of DMR SNPs across SCZ, BPD, BMI and Height. Quantile-Quantile (QQ) plots of GWAS SNPs for Schizophrenia (SCZ) with the extended MHC region masked (chr6: 25-35 Mb), Bipolar Disorder (BPD), Body Mass Index (BMI) and Height. The X-axis shows expected -log10 p-values under the null hypothesis. The Y-axis shows actual observed -log10 p-values. The values for all GWAS SNPs are plotted in pink while the values for SNPs in linkage disequilibrium (LD) with DMRs are plotted in blue. Leftwards deflections from the null line (grey diagonal line) indicate enrichment of true signals - the greater the leftward deflection, the stronger the enrichment. Genomic correction was performed on all SNPs with global lambda

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